Abstract
Endothelin 1 has many biological activities including actions in the nervous system. This study aimed to investigate the expression of the endothelin 1 in spiral ganglion cells of guinea pig and its significance in the auditory transmission. Healthy guinea pigs were sacrificed and cardiac perfused with saline followed by 4% paraformaldehyde. Temporal bones were removed and fixed, decalcified in 10% EDTA, embedded in paraffin block and serially sectioned in 5 microm thick slice. Rabbit anti-endothelin 1 polyclonal antibody was used as primary antibody to examine the expression of endothelin 1 in the spiral ganglion by immunohistochemistry. Endothelin 1 expression was detected in spiral ganglion cells from the basal turn to the apical turn of the cochlea. The endothelin 1 presents in spiral ganglions cells of the guinea pig and might play a role in the auditory transmission.
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