Abstract
Objective To explore the expression and significance of vaccinia virus-associated kinase 1 (VRK1) in glioma. Methods Western blotting was used to detect the protein expression levels of VRK1 in glioma tissues. Kaplan-Meier was applied to analyze the relationship between VRK1 and prognosis parameters. The expression of VRK1 in glioma cells RNA interference on. Cell counting kit-8 (CCK-8) cell counts and colonies for analysis of cell proliferation. Results Western blotting showed that VRK1 protein is highly expressed in glioma tissues. The expression of VRK1 was not significantly correlated with gender and age of glioma patients (P=0.556), while VRK1 expression was significantly with WHO classification (P=0.002). Kaplan-Meier analysis found that patients with high expression of VRK1 had a poor prognosis (P=0.050). The CCK-8 cell count and colony results indicate that VRK1 promotes glioma cell proliferation. Conclusion The high expression of VRK1 in glioma patients is related to the development of glioma. Key words: Vaccinia virus-related kinase 1; Glioma; Survival analysis
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