Abstract

Summary In 5 of the 9 known cases of agenesis of the sacrum reported in Czechoslovakia between 1959 and 1966, a history of close contact during pregnancy with organic solvents (xylene, trichloroethylene, methylchloride, acetone, petrol) was obtained. Experiments with chick embryos exposed to xylene tend to support the hypothesis that fat solvents may have some teratogenic effect and cause the production of sacral agenesis in man.

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