Exploring unusual cutaneous manifestations in Dowling–Degos disease: A rare case report

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Dowling Degos Disease (DDD) is also referred to as post-pubertal reticulate hyperpigmentation or reticular pigmented anomaly of the flexures. It is an extremely uncommon disorder that typically manifests as reticulate hyperpigmentation of the flexures, comedo-like follicular papules, and pitted perioral scars. Dowling and Freudenthal published the first literary description of it in 1938, and Jones and Grice classified it clinically and histopathologically in 1978. It is an uncommon autosomal dominant genodermatosis, and it often manifests after puberty, more especially in adults. Mutations in the genes KRT5, POFUT1, POGLUT1, and most recently PSENEN are thought to be the primary cause of DDD.