Abstract
BackgroundOvarian cancer is a common cancer type in women and is often associated with onset of malnutrition. Total parenteral nutrition (TPN) is a nutritional intervention method that has been reported to have controversial effect on cancer patients. In the present retrospective study, we sought to explore the prevalence of malnutrition assessed by the Nutritional Risk Index (NRI) and its association with survival in advanced stage ovarian cancer patients. We also compared the post-operative outcome of the malnourished patients treated with either TPN or conservative management.ResultsA total of 415 patients with advanced stage ovarian cancer were separated into 4 nutrition groups based on the NRI scores. We found that a number of factors were significantly different among the 4 nutrition groups, including age, serum albumin level, BMI and NRI; among which serum albumin level and NRI were identified to be independent predictors of progression-free and overall survival. In the moderately and severely malnourished patients, those who were treated with TPN had significantly shorter hospitalization period, lower serum albumin level and lower BMI after surgery. In addition, serum albumin level, use of TPN and number of patients with complications were closely related to the hospital stay duration.ConclusionMalnutrition status is closely associated with survival of advanced stage ovarian cancer patients. These patients may benefit from TPN treatment for reduced hospitalization, especially with the onset of hypoalbuminemia.
Highlights
Ovarian cancer is a common cancer type among all cancers in women, with over 200 thousand new cases diagnosed worldwide [1]
Patient characteristics A total of 415 patients who had undergone cytoreductive surgery incorporating bowel resection for advanced epithelial ovarian cancer were included in the present study
Patients were separated into nourished, mildly malnourished, moderately malnourished and severely malnourished groups based on the Nutritional Risk Index (NRI) score
Summary
Ovarian cancer is a common cancer type among all cancers in women, with over 200 thousand new cases diagnosed worldwide [1]. Yan et al BMC Cancer (2021) 21:799 body mass index (BMI) have been employed to assess the nutrition status in cancer patients [5,6,7]. The Nutritional Risk Index (NRI) was developed to assess the nutrition status in malnourished surgical patients [11]. It combines serum albumin level with body weight changes and is a relatively simple and accurate tool to objectively assess nutrition status without the need for any special training [12, 13]. In the present retrospective study, we sought to explore the prevalence of malnutrition assessed by the Nutritional Risk Index (NRI) and its association with survival in advanced stage ovarian cancer patients. We compared the post-operative outcome of the malnourished patients treated with either TPN or conservative management
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