Abstract
The construction of physical models for virus capsids that utilize the simple elastic network description for strain induced by local structural distortions is reviewed. Following, a brief overview of normal mode methods and computational schemes that yield information regarding the dynamics of viral capsids and their response to structural perturbations is given. Finally, these approaches will be illustrated via applications to the swelling of several viruses, with attention focused on the similarities and differences in the pathways of conformational distortions that arise for capsids with different quasi-symmetry T numbers. Examples to be discussed include a T 1⁄4 3 virus (CCMV), a capsid displaying T 1⁄4 4 quasi-symmetry (NwV) and a T 1⁄4 7 capsid (HK97).
Highlights
The construction of physical models for virus capsids that utilize the simple elastic network description for strain induced by local structural distortions is reviewed
A brief overview of normal mode methods and computational schemes that yield information regarding the dynamics of viral capsids and their response to structural perturbations is given
These approaches will be illustrated via applications to the swelling of several viruses, with attention focused on the similarities and differences in the pathways of conformational distortions that arise for capsids with different quasi-symmetry T numbers
Summary
The construction of physical models for virus capsids that utilize the simple elastic network description for strain induced by local structural distortions is reviewed.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Computational and Mathematical Methods in Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
