Exploratory Analysis of the Economically Justifiable Price of Tezepelumab for asthma severe in Colombia

Abstract

Introduction Asthma severe imposes important economic burden for health systems, especially with the incorporation of new drugs. Recently, tezepelumab has been approved to prevent exacerbations in patients. This study explores the economically justifiable price of tezepelumab for preventing exacerbations in patients with severe asthma. Materials and methods A static model was developed using the decision tree microsimulation to estimate the quality-adjusted life years of two interventions: a single intramuscular dose of tezepelumab versus not applying tezepelumab. This analysis was made during a time horizon of 50 year and from a third payer perspective. Results Based on thresholds of U$4828, U$5128, and U$19 992 per QALY evaluated in this study, we established economically justifiable drug acquisition prices of U$795, U$835, and U$3384 per dose of Tezepelumab. Tezepelumab not was cost-effective using a WTP of U$4828 and U$5128. It only was cost effective at WTP of U$19 992 per QALY Conclusion The economically justifiable cost for tezepelumab in Colombia is between U$795 to U$3384 per dose, depending on the WTP used to decide its implementation. This result should encourage more studies in the region that optimize decision-making processes when incorporating this drug into the health plans of each country.