Abstract
Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.
Highlights
Pediatric asthma is a common disease in children
The study showed that vitamin D supplements not airway inflammation by activating proinflammatory genes to only prevented vitamin D deficiency (VDD) and reduced acute asthma attacks promote the release of airway hyperresponsiveness mediators, caused by acute respiratory tract infections (ARTI) [33, 34]
Eighty-nine children with asthma were divided into decreased lung function (FEV1 and forced vital capacity (FVC)) and increased risk the placebo group (PG) (n = 35) and vitamin D group (VDG)
Summary
Pediatric asthma is a common disease in children. Shortness of breath, chest tightness, asthma, and repeated coughing often occur or worsen at night and/or in the morning. Research has shown that vitamin D regulates more than 5% of human genes, regulates the expression of 291 genes in leukocytes, and participates in more than 160 different biological metabolic pathways, inducing physiological responses in 36 different cell types [3, 4]. Among these genes, those related to the human immune response are an area of concern. The immunomodulatory function of vitamin D can increase the production of antimicrobial peptide (AMPs) such as cathelicidin These immunomodulations prevent bacterial/viral infections, reduce asthma attacks, improve airway function, increase responsiveness to GCS and have clinical benefits [12]. The results of clinical trials have led to some different conclusions [16, 17]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
