Exploration of a Traditional Nanomedicine - Mukta Pishti Subjected to Bhavana with Gulaba Arka for 3, 7, and 21 Days

Chitin is a linear homo-polymer of N-acetyl-D-glucosamine (GlcNAc) and the second most abundant biopolymer after cellulose. Several industries rely on the bioprocesses for waste chitin recycle and hydrolysis by chitinase (EC 3.2.1.14) for potential healthcare applications through the production of its monomeric subunit, GlcNAc. In the present study, a chitinase-producing fungus (named as MFSRK-S42) was isolated from the marine water sample of North Bay of the Andaman and Nicobar Islands. It was identified as Aspergillus terreus by morphological and molecular characterization methods leveraging the internal transcribed spacer between 18S rRNA and 5.8S rRNA. Chitinase that was isolated from the fermentation broth of marine Aspergillus terreus was used to carry out biotransformation of chitineaceous wastes. Prior to the enzymatic hydrolysis step, chitins from different sources were characterized for the presence of characteristic functional groups, grain size distribution, and surface morphology. Enzymatic hydrolysis of 50mg/ml substrate with six units of enzyme incubated for 5days revealed 15, 36.5, 40, and 46mg/ml GlcNAc production from ground prawn shell, chitin flakes, colloidal prawn shell, and swollen chitin respectively under standardized conditions, as determined by HPLC. In this study, 30, 73, 80, and 92% GlcNAc yields were observed from ground prawn shell, chitin flakes, colloidal prawn shell, and swollen chitin conversion respectively. The HPLC-eluted product was confirmed as GlcNAc by the presence of characteristic functional groups in FTIR and 244Da molecular weight peak in HRMS analyses.

Control of aragonite formation and its crystal shape in CaCl2-Na2CO3-H2O reaction system

The extent to which calcium carbonate deposition in an anaerobic reactor can be reduced by adding inhibitors (phosphate and iron) of calcium carbonate crystal growth was investigated. At several concentrations of the additive, the extent of precipitation was assessed in continuous experiments with laboratory-scale reactors. In the reactor, phosphate concentrations as low as 0.5–5 mg total-P dm−3 were found to severely inhibit CaCO3 precipitation. However, iron did not inhibit the deposition of CaCO3, which was found to be due to the fact that iron, in contrast to phosphate, only inhibits the growth of calcite and not the formation of aragonite. The results led to the conclusion that only additives which inhibit the formation of both aragonite and calcite can be used as effective inhibitors during anaerobic digestion. A chemical equilibrium model was developed and shown to be a useful tool to calculate the extent of calcium carbonate deposition during anaerobic digestion provided the proper apparent solubility product of calcium carbonate can be estimated. © 1999 Society of Chemical Industry

The author has shown the effect of various inorganic ions on the polymorphic crystallization of calcium carbonate from a bicarbonate solution. No definite conclusion regarding the mechanism to give calcite, aragonite or vaterite can yet be made, but these data help to give a pattern of the influence of inorganic ionic species and the concentration of the mother solution on the polymorphic crystallization of calcium carbonate. (1) Alkali chlorides in the mother solution inhibited aragonite formation and favored calcite formation. The extent of the inhibition of the aragonite formation decreases in the sequence: ammonium chloride>lithium chloride, sodium chloride>potassium chloride >rubidium chloride, >cesium chloride (sodium nitrate). (2) (a) Sodium chloride and sodium nitrate in the mother solution inhibited aragonite formation, sodium chloride more strongly than sodium nitrate, (b) With a moderate increase in the amount of sodium bicarbonate (sodium carbonate) added to the mother solution, the percentage of aragonite formation increased to a maximum. With a further increase in the amount, however, the percentage began to decrease and reached zero, (c) When sodium hydroxide was added to the mother solution, only calcite was formed. Aragonite was never formed from the solution which had made alkaline with sodium hydroxide, (d) The presence of sulfate ions favored aragonite formation. (3) (a) Magnesium ions in the mother solution favored aragonite formation very strongly. The presence of magnesium chloride in the mother solution was more favorable to aragonite formation than that of magnesium bicarbonate or magnesium sulfate. Magnesium was not co-precipitated with calcium carbonate, (b) The presence of calcium chloride in the mother solution had no effect on the crystallization. (c) With an increase in the strontium concentration in the original solution, the percentage of aragonite formation increased to a maximum (optimum strontium content: approximately 2 mg./l). The percentage began to decrease with a further increase in strontium concentration. The strontium was always entrained in calcium carbonate precipitates, even when the strontium concentration was very low. (d) The presence of a small number of barium ions in the mother solution favored calcite formation. The presence of a large number of barium ions favored vaterite formation. Even at a low concentration in the mother solution, barium was always entrapped in the precipitates.

Although pearls are well known by most people, their medicinal value has not been popularized. This article collates the medicinal history of pearls over 2,000 years in China, including the application of pearls in the traditional medicine of China and their various preparations, as well as the progress of their chemical constituents, pharmacology, toxicology, and clinical research. Pearls from three different sources are used as medical materiel by 9 nationalities and 251 prescription preparations in China. In addition, pearls contain various inorganic constituents, such as calcium carbonate, trace elements, and water, and organic constituents, such as amino acids. In terms of pharmacology, pearls have many effects such as calming, improving cognitive ability, being anti-epileptic, promoting bone growth and regeneration, promoting the proliferation and migration of human microvascular endothelial cells, protecting the heart, anti-hemolysis, and anti-oxidation. In terms of toxicology, pearls are safe to take for a long time without exerting obvious adverse reactions. In terms of clinical application, pearls have been used to treat many diseases and conditions, such as convulsions, epilepsy, palpitations, eye diseases, ulcer diseases, skin diseases, or skin lesions. This article provides a reference for the application and research of pearls in the future.

Production of aragonite whiskers by carbonation of fine recycled concrete wastes: An alternative pathway for efficient CO2 sequestration

In vitro evaluation of silver doped wollastonite synthesized from natural waste for biomedical applications

Supersaturation control in aragonite synthesis using sparingly soluble calcium sulfate as reactants

Background: Recent research has brought attention to the bioactive properties of dairy fats, leading to a shift in the scientific community’s perspective. Ghee, a clarified butter integral to Indian culture and cuisine, has been extensively documented in Ayurveda for its therapeutic benefits. Objective: To examine the health benefits of ghee as described in Ayurvedic texts and modern scientific literature, identifying areas of alignment and divergence. Methods: Ayurvedic Review: Analysis of 11 classical texts spanning 3000+ years, identifying 4000 references to milk derivatives, including 774 mentions of ghee. Benefits were categorised into 15 clusters. Modern Literature Review: Examination of studies published between 1990 and 2023, focusing on ghee’s therapeutic applications. Results: Ayurvedic Insights: Ghee is highlighted for cognitive enhancement, gastrointestinal health, and nourishment, with 2913 references to the benefits of milk derivatives. Modern Insights: Research primarily emphasises ghee’s role in wound healing, skin health, and cardiovascular benefits. Discussion: Ayurvedic and modern perspectives offer complementary insights. While modern science has explored ghee’s topical and cardiovascular applications, Ayurveda underscores its systemic benefits, including cognitive and digestive health. Conclusion: The integration of Ayurvedic knowledge and modern science could unlock ghee’s therapeutic potential, addressing chronic and age-related diseases. Future interdisciplinary research is crucial for validating traditional applications and discovering innovative treatments.

Anovulation, the failure of the ovary to release an egg during the menstrual cycle, is a common cause of infertility in women. In Ayurveda, anovulation is linked to infertility—is referred to with terms like Artavkshaya,Nashtartava, Anartava, and Nashta beejam. Ayurvedic texts describe this condition as a disruption of the reproductive system's normal function, often attributed to imbalances in Vata specially apan vata and Kapha dosha as well as blockages in the Artavavaha srotas (reproductive channels). Such imbalances can result in the absence of ovulation, conventional treatments for anovulation often involve hormonal therapies, which may have side effects and limited efficacy in some cases. Laghumalini Vasant, a traditional Ayurvedic formulation, has been historically used to enhance reproductive health and address fertility disorders. This paper explores the potential role of Laghumalini Vasant in the management of anovulation, focusing on its ability to regulate hormonal imbalances, support ovarian function, and promote regular ovulation by improving rasa dhatwagni.The formulation contains a blend of herbs and minerals that are believed to act synergistically to enhance fertility. By analyzing traditional Ayurvedic knowledge and contemporary clinical perspectives, the study highlights how Laghumalini Vasant could serve as a complementary treatment in managing anovulatory conditions. While traditional usage and anecdotal evidence support its efficacy, further clinical research is required to substantiate its effectiveness in treating anovulation and related fertility issues.

Influence of acid-soluble proteins from bivalve Siliqua radiata ligaments on calcium carbonate crystal growth

The scientific perspective on dairy fats, including ghee, is evolving. In the past, dairy fats were thought to have adverse health effects, but recent research is revealing their functional benefits and the positive aspects of their fatty acids. This shift in scientific understanding has sparked interest in ghee, a clarified butter derived from milk, which holds cultural significance in India and plays a prominent role in Ayurvedic medicine. While modern scientific studies on ghee’s benefits are limited, Ayurvedic literature extensively documents its therapeutic potential, categorizing different types of ghee based on factors like milk source, manufacturing methodand maturation. To explore ghee’s therapeutic potential further, researchers conducted a review comparing Ayurvedic literature to modern scientific studies. These mentions were grouped into various health benefit clusters. While recent research emphasized cardiovascular health and skin benefits, Ayurveda, an ancient medical system, has emphasized cognitive benefits, gastrointestinal healthand overall nourishment. These aspects are gaining significance as the world’s population ages and chronic diseases become more common. As scientists work to address these health issues, they can look to the detailed descriptions in Ayurvedic texts. These texts provide information about the animal sources of ghee, how it is processedand how it is aged, as well as its associated health benefits. This knowledge could offer valuable insights for guiding future research efforts. Exploring ghee’s traditional usage and formulations could lead to new scientific discoveries and potentially innovative approaches to addressing modern health challenges.

: Ayurvedic medication pancha nimba choorna is a herbal powder. The panchanimba is a well-known medication stated in the old Ayurvedic texts used to cure kshudra kushtas (minor skin disorders), such as eczema, acne, and Maha kushtas (major skin ailments).It is used to treat a variety of skin conditions, including dermatitis, pruritis, psoriasis, sinus, non-healing wounds, headaches, uti, diabetes, toxins, and arthritis. It is employed to treat infections of the skin.The traditional use of the neem tree's leaves, blossoms, seeds, fruits, roots, and bark for the treatment of inflammation, infections, fever, skin conditions, and dental problems includes all of these parts. Neem leaf's therapeutic benefits have been specifically discussed. The immunomodulatory, anti-inflammatory, anti-hyperglycaemic, antiulcer, antimalarial, antifungal, antibacterial, antiviral, antioxidant, antimutagenic, and anticarcinogenic activities of neem leaf and its components have been proven. Protein, carbohydrates, flavonoids, phenol, saponin, glycosides, tannin, and alkaloids are all present according to phytochemical analysis, whereas terpenoids, sterols, and other substances are not present.To guarantee the quality of the product, standardization employing various parameters was used which was performed as per the Indian Pharmacopoeia, WHO guidelines and various literature reports. The antioxidant activity may be attributes to flavonoids and phenolics present in extracts of . In terms of gallic acid equivalent, Panchanimb Churna contained 105 mg/g of total phenols and the total flavonoid concentration was 43.8214 mg/g, which is the quercetin equivalent.Antioxidant property was evaluated using DPPH activity.According to a forementioned quality criterion, Panchanimb Churna was determined to be competent under every examined aspect. The current study strengthens belief in herbal remedies of natural origin to combat infectious diseases and other illnesses that may be included in medications in the future. Overall the product is very beneficicial in day to day life for humans as it possess various qualities and activities.

Effect of Aging Time in the Synthesis of Biogenic Hydroxyapatite Derived from Cockle Shell

Precipitation and dissolution mechanisms of calcium carbonate are important processes for the regulation of pH in natural waters and for the transport of pollutants to and from the sediments. In the present work the precipitation of calcium carbonate in supersaturated solutions made from synthetic seawater was investigated by the introduction of calcite seed crystals at conditions of sustained solution supersaturations. Aragonite was found to form on the calcite seed crystals when the magnesium concentration was 53.3mM, while below this concentration calcite was the only phase forming. The kinetics of formation of both calcite and aragonite showed strong dependence on the solution supersaturation and the apparent order was found to be 7, suggesting a polynuclear mechanism. Throughout the crystal growth process the number of seed crystals remained constant, while their size increased.