Abstract
The utility of the J-HSMQC experiment to detect long-range CH correlations was investigated. Two new long-range J-compensated pulse sequences, LR- J-HSMQC(80,27) and LR- J-HSMQC(27,80), were developed using the (3β x )β y composite 90° pulse sequence. These two experiments were shown to be effective for long-range coupling constants, n J CH, that were greater than 3 Hz. Although the overall sensitivities of the long-range J-HSMQC experiments were slightly lower than that of the conventional decoupled HMBC experiment, their 2D maps showed additional cross peaks that could be useful in structure elucidation. LR- J-HSMQC(27,80) was very efficient in yielding two- and four-bond relay correlations. The utility of the new sequences is demonstrated with strychnine as the sample.
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