Abstract
Optical methods for biomedical purposes mostly use reflected light, while few of them use the transmitted light. The blood vessels pose a challenge to these methods due to their high absorption and scattering coefficients as well as their change in size during respiration, and they are also naturally distributed in size within the body and between individuals. We suggest the full scattering profile (FSP) method in order to investigate the light at every possible exit angle. Our model of FSP successfully describes the role of the blood vessel diameter in light-tissue interaction. By means of the new point of view of FSP, we found the isobaric point, which is non-dependent on the optical properties. The uniqueness of the isobaric point is that it overcomes the shielding effect, which has known influence on the reflected light, for various vascular diameters of the same volume. We present these findings experimentally by measuring cylindrical phantoms with blood vessels in different diameters, and compare the results to our simulation results. The importance of the immunity to the shielding effect is that it allows self-calibration in clinical measurements and decreases the calibration error. In addition, by using the isobaric point we can cope with changes in blood vessel diameters and not assume microcirculation only.
Highlights
In recent years, optical methods are very useful in the detection of various physiological states
We presented our new system for measuring the full scattering profile (FSP) of cylindrical tissues [12]
By investigating the blood vessel diameter's influence on the FSP, we presented in a simulation as well as an experimentally, the shielding effect in the FSP
Summary
Optical methods are very useful in the detection of various physiological states. We discussed the shielding effect in the FSP of cylindrical silicon-based phantoms with blood vessels larger than 1 mm. We can use the isobaric point as a self-reference point for extracting optical properties in clinical applications, even though the blood vessels change their size during respiration, as they do in various physiological conditions. It can be useful for more accurate blood perfusion measurements and blood oxygen saturation determination. The standard deviation due to capillaries' placement is presented in the results
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
