EXPERIMENTAL STUDY ON PERIPHERAL CIRCULATORY DISTURBANCES AND INNER EAR CHANGES DUE TO LOCAL ALLERGIC REACTION

Abstract

(1) Observations were made of local allergic reactions in rabbits and guiner pigs whose conjunetiuae had beeniniected with antigens. Leitz's panphotometer was employed for studying the animals' changes in blood vessels and blood flow.(2) There weye observed vascular dilation, slow blood flow fibrinogen thrombosis which suggested plasma space, blood flow defect which suggested a swelling of endothelial cells, petechy, interrupted bloodflow, sludged blood and stasis. The above changes were classified into tentatively designated Sakai & Hazama's classifications.(3) The above changes usually developed in 5 minutes, reaching their maximum in 15-30 minutes and gradually recovered in 24-48 hours.(4) For 48 Hours following injection of an antigen into sensitized guiner pigs' tympanium their vestibuler function was studied with post rotatory nystagmus test. A histological survey was also made with inner ear specimens.(5) An hour after the injection of an antigen the animal's vestibuler function and inner ear histological finding showed no changes.48Hours after the injection, there developed an increase or an increase followed by a decrease in vestibuler function as well as considerably extensive changes in inner ear tissues.But of 20 cases 11 cases (55%) showed endolymphatic hydrops.(6) For 48hours after application of an antigen to the region of the internal auditory portus of sensitized gainer pigs, the animal's vestibular function was studied with post rotatory nystogmus test. A histological survey was also mede with inner ear specimens.(7) 10 to 30 minutes after the application many of the animals developed an increase or increase followed by decrease in spontaneus vestibular function. The results of the post rotatory nystagmus test obviously showed the above changes; an hour after the application inner ear tissues showed slight changes which become considerably marked 48 hours after the application. 25 cases (78%) of the 32 cases studied showed spontaneous vestibular distarbances, and 11 cases (37%) of them showed spontaneous nystagmus. 7 cases (35%) of the 20 cases who had been observed for 48hours showed endolymphatic hydrops.(8) Since the findings of conjunctival blood vessels and the changes in vestibular function in the inner auditory portus region application group were chronologically correspondent, it was assumed that similar changes had developed in inner ear blood vessels.(9) The inner auditory portus application group showed slighter changes than the tympanum administration group. It seems that the former showed spontaneous vestibular symptoms developing very rapidly.(10) From the above experiments it was assumed that Meniere's disease develops due to disturbances in inner ear peripheral blood circulation being considerably attributable to allergic reactions.