Abstract
In conclusion, the histogenesis of cervical carcinomas induced in mice by coaltar hydrocarbons or inactivated herpes simplex virus, types 1 and 2, has been described. The lesions antedating the development of squamous cell carcinoma were similar to lesions encountered in patients with the same keratinizing type of carcinoma of the ectocervix. A theory for the development of the three grades of human cervical squamous cell carcinoma has been presented based on experimental and clinical data which demonstrate that each of the three grades of cancer consists of cells which resemble those of the tissue of origin and of the antecedent noninvasive lesion.
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