Abstract
Heinz bodies were produced in pigs given a single injection of hydroxylamine or acetyl-phenylhydrazine, but were not produced with nitrite. Heinz bodies were in 90–95% of erythrocytes by 2 hours after injection of hydroxylamine and in 95–100% of erythrocytes by 24 hours after administration of acetylphenylhydrazine. The percentage of affected erythrocytes gradually declined to 40–50% at necropsy on day 17. Anemia was not produced, nor were there clinical signs that could be attributed to the presence of Heinz bodies. There was histologic evidence of increased hemosiderosis in the spleen and of increased bone marrow activity.
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