Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current public health crisis with devastating consequences to our societies. This COVID-19 pandemic has become the most serious threat to global public health in recent history. Given the unprecedented economic and social impact that it is causing, identification of immunodominant epitopes from SARS-CoV-2 is of great interest, not only to gain better insight into the adaptive immune response, but also for the development of vaccines, treatments and diagnostic tools. In this review, we summarize the already published or preprinted reports on the experimental identification of B-cell linear epitopes of SARS-CoV-2 proteins. Six different epitopes leading to neutralizing antibodies have been identified. Moreover, a summary of peptide candidates to be used for diagnostic tools is also included.
Highlights
A novel infectious disease attributed to a coronavirus was first reported in late 2019 (COVID-19).[1]
Given the unprecedented economic and social impact that it is causing, identification of immunodominant epitopes from SARS-CoV-2 is of great interest, to gain better insight into the adaptive immune response, and for the development of vaccines, treatments and diagnostic tools
This infectious disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) had reached enough countries to be declared a pandemic by the World Health Organization (WHO)
Summary
A novel infectious disease attributed to a coronavirus was first reported in late 2019 (COVID-19).[1]. Within months, this infectious disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) had reached enough countries to be declared a pandemic by the World Health Organization (WHO). SARS-CoV-2 belongs to the betacoronavirus family and has high homology to SARS-CoV (79% sequence identity[3]), the virus responsible for the 2002–2004 outbreak.[4]. Based on this homology it was rapidly established that the spike protein, which protrudes from the surface of the viral particles, is responsible for host cell recognition and entry through its interaction with angiotensin-converting enzyme 2 (ACE-2).[5,6]. This review summarizes the work done by several groups on the experimental identification of immunodominant B-cell linear epitopes of SARS-CoV-2 proteins and its comparison to the ones found in SARS-CoV
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