Experimental evaluation of the specific activity of the new Angiolin dosage form in the research corneal burn's condition

Abstract

Visual organ injuries are still one of the main causes of blindness and occupational disability. Despite the good protection of the eyeball by the bone walls of the orbit and adnexa oculi, its injuries are 5–10 % of the total number of all damages in peacetime and about 20 % in wartime. Employees of the Department of Pharmaceutical Chemistry of Zaporizhzhia State Medical University (ZSMU) together with the specialists of the SPA “Farmatron” under the supervision of professor I. A. Mazur synthesized a new compound, called Angiolin. The aim of the research is to study the anti-inflammatory, wound-healing, reparative activity of the Angiolin eye drops action during a chemical burn of the cornea rabbits modeling. Materials and methods: The pharmacological efficacy of the prepared Angiolin eye drops in concentrations: 0.5 %, 1.0 %, 1.5 %, 2.0 % and 2.5 % has been studied. All studies were carried out on 40 eyes of 20 Chinchilla breed rabbits of both sexes weighing 2.1–3.5 kg. The chemical burn model was reproduced according to the Obenberger method using 10 % sodium hydroxide solution (application of8 mm blotting paper), exposure time 20 seconds, after preliminary installation anesthesia with 0.5 % Alcaine solution. Results. Based on experimental data, it can be noted that Angiolin eye drops in concentrations: 1.0 %, 1.5 %, 2.0 %, 2.5 % show almost the same pharmacological activity, and 1 % Angiolin eye drops were the most effective, that gives us the opportunity for further study. Conclusions. Angiolin eye drops exhibit high anti-inflammatory, wound healing, reparative activity in the treatment of eye burn. As a result of the study, it was found that 1 % of Angiolin eye drops turned out to be the most effective. The obtained results are an experimental rationale for further study of 1 % Angiolin eye drops.