Abstract
Objective: to study the efficacy of sulpiride in different types of non-psychotic types of endogenous depressive-hypochondriacal syndrome. Patients and methods. Forty-seven patients (36 women and 11 men) with a depressive episode (n = 15), recurrent depressive disorder (n = 14), and slowly progressive schizophrenia (SPS) (n = 18) were examined clinically and using the psychometric scales: the Clinical Global Impression Scale; Montgomery-Esberg Depression Rating Scale (MADRS), the Hamilton Anxiety Rating Scale (HARS), and Udvalg for Kliniske Undersшgelser Side Effect Rating Scale. Sulpiride was given in an initial dose of50—100 mg/day; the dose was, if required, increased up to 400—600 mg/day. Results. After 2 months of treatment in the patients with affective disorders, the MADRS and HARS scores showed reductions from 28.7+2.3 to 14.3+1.7 and from 14.8+2.1 to 7.4+2.7, respectively. The reductions in the symptoms of depression and anxiety were 50.2 and 50.0%, respectively. In SPS, the mean MADRS and HARS scores decreased from 21.4+3.7 to 13.7ё1.8 and from 10.2+1.5 to 6.4+3.2, respectively. There were generally 40 and 37.3% reductions in the symptoms of depression and anxiety, respectively. Conclusion. In patients with affective disorders, the efficacy of sulpiride is predominantly due to its antidepressant and anti-anxiety activities in depressive-hypochondriacal syndrome and to its antipsychotic and activating activities in SPS.
Highlights
Objective: to study the efficacy of sulpiride in different types of non-psychotic types of endogenous depressive-hypochondriacal syndrome
Sulpiride was given in an initial dose of 50—100 mg/day; the dose was, if required, increased up to 400—600 mg/day
In patients with affective disorders, the efficacy of sulpiride is predominantly due to its antidepressant and anti-anxiety activities in depressive-hypochondriacal syndrome and to its antipsychotic and activating activities in slowly progressive schizophrenia (SPS)
Summary
Lanska D.J., Hoffmann R.G. Seasonal variation in stroke mortality rates. Современное состояние проблемы острого ишемического инсульта в Японии: результаты общенационального госпитального исследования 1999–2000. Цель исследования — изучение эффективности сульпирида при различных вариантах эндогенного депрессивно-ипохондрического синдрома непсихотического уровня. Через 2 мес лечения в группе больных с аффективными расстройствами произошло снижение показателей шкалы MADRS c 28,7±2,3 до 14,3±1,7; HARS – c 14,8±2,1 до 7,4±2,7. При ВШ средние показатели шкалы MADRS уменьшились с 21,4±3,7 до 13,7±1,8; HARS с 10,2±1,5 до 6,4±3,2 балла. After 2 months of treatment in the patients with affective disorders, the MADRS and HARS scores showed reductions from 28.7±2.3 to 14.3±1.7 and from 14.8±2.1 to 7.4±2.7, respectively. The reductions in the symptoms of depression and anxiety were 50.2 and 50.0%, respectively. There were generally 40 and 37.3% reductions in the symptoms of depression and anxiety, respectively
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