Abstract
Acute inflammatory demyelinating polyneuropathy Guillain – Barre syndrome (AIDP-GB) – acquired immune mediated disease with acute onset characterized by the development of peripheral tetraparesis due to immune system attack to peripheral nerves and spinal roots. This article describes the case report of AIDP-GB development in the patient with hepatitis C and type 2 diabetes mellitus. The patient was treated with course of plasmapheresis and subsequent course of intravenous immunoglobulin (IVIG) for increasing the effectiveness of therapy. During the therapy, there was a significant improvement in the condition of patient and reduction of neurological deficit, confirmed by neurological examination and electroneuromyography, immediately after treatment and in 6 months. In addition, rehabilitation measures for the patient included physical therapy, including physiotherapy and acupuncture. To sum up, the effective treatment of AIDP-GB includes pathogenic therapy (plasmapheresis, IVIG) and rehabilitation measures to facilitate the recovery of the patient and return to professional practice.
Highlights
Острая воспалительная демиелинизирующая полирадикулоневропатия Гийена – Барре (ОВДП-ГБ) – приобретенное иммуноопосредованное заболевание с острым началом, характеризующееся развитием периферического тетрапареза вследствие поражения нервных стволов и корешков клетками собственной иммунной системы
Acute inflammatory demyelinating polyneuropathy Guillain – Barre syndrome (AIDP-GB) – acquired immune mediated disease with acute onset characterized by the development of peripheral tetraparesis due to immune system attack to peripheral nerves and Voinov V
The patient was treated with course of plasmapheresis and subsequent course of intravenous immunoglobulin (IVIG) for increasing the effectiveness of therapy
Summary
Acute inflammatory demyelinating polyneuropathy Guillain – Barre syndrome (AIDP-GB) – acquired immune mediated disease with acute onset characterized by the development of peripheral tetraparesis due to immune system attack to peripheral nerves and Voinov V. The effective treatment of AIDP-GB includes pathogenic therapy (plasmapheresis, IVIG) and rehabilitation measures to facilitate the recovery of the patient and return to professional practice. V. Experience in the use of plasmapheresis in acute inflammatory demyelinating polyradiculoneuropathy Guillain – Barre syndrome in the patient with chronic hepatitis C virus infection and type 2 diabetes mellitus. Цельная кровь забирается у пациента через венозный доступ и пропускается через экстракорпоральный контур аппарата, в котором находится сепаратор плазмы. За процедуру удаляется до 1000 мл плазмы, возмещаемой лишь изотоническим раствором натрия хлорида без использования донорской плазмы, что делает такую процедуру более безопасной. Состоящий из 4 таких процедур, удаляется до 1,5 объема циркулирующей плазмы. При этом важно не только удалить сформировавшиеся аутоантитела и цитокины, но и подавить активность их продуцентов – В- и Т-лимфоцитов
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