Abstract
Peste des petits ruminants (PPR) is a severe respiratory and digestive tract disease of domestic small ruminants caused by PPR virus (PPRV) of the genus Morbillivirus. Although the primary hosts of PPRV are goats and sheep, the host range of PPRV has been continuously expanding and reported to infect various animal hosts over the last decades, which could bring a potential challenge to effectively control and eradicate PPR globally. In this review, we focused on current knowledge about host expansion and interspecies infection of PPRV and discussed the potential mechanisms involved.
Highlights
Peste des petits ruminants (PPR) is a highly contagious fatal viral disease of small ruminants characterized by fever, pneumonia, diarrhea, and inflammation of the respiratory and digestive tracts
PPR virus (PPRV) primarily infects goats and sheep, but over the last decades the host range of PPRV has been continuously expanding to many other non-natural hosts by unknown mechanisms.This indicates that PPRV has a potential capability of adapting to various new hosts, which might impact on the successful implementation of the PPR global eradication plan
This study has shown that the animals raised in agropastoral (AP) has seroprevalence rate of 5.8%, whereas 30.7% sero prevalence was observed in pastoral (P) villages in northern Tanzania indicating that even the management system affects the PPRV infection [87]
Summary
Peste des petits ruminants (PPR) is a highly contagious fatal viral disease of small ruminants characterized by fever, pneumonia, diarrhea, and inflammation of the respiratory and digestive tracts. There are increasing reports of PPRV infection in other domestic and wild animals with or without showing clinical symptoms (Table 1).
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