Abstract
Exercise induced anaphylaxis is a dramatic expression of physically induced mast cell stimulation (1). It may be difficult to distinguish from cholinergic urticaria, since both diseases may be associated with exercise. A young man with recurrent exercise associated allergic manifestation was studied with exercise challenge and serial plasma histamine measurements. The finding of exercise associated mediator elevation in the absence of signs or symptoms of anaphylaxis has implications for future management and studies of patients with exercise induced allergic disease.
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