Abstract

Exercise has profound effects on whole body metabolism through adaptations to various tissues including adipose tissue. Several recent studies have investigated exercise‐induced adaptations to two white adipose tissue (WAT) depots, inguinal WAT (ingWAT) and perigonadal WAT (pgWAT), and one brown adipose tissue (BAT) depot, interscapular BAT (iBAT), and shown that each adipose tissue (AT) depot has a distinct response to exercise. Here, we investigated the effects of exercise on each of the 14 AT depots in the body. Ten week old male C57BL/6 mice housed in static cages (sedentary) or were given open access to a running wheel (exercise‐trained) for 3 weeks, and each adipose depot was removed. Exercise increased mitochondrial activity in ingWAT, and pgWAT, and decreased mitochondrial activity in iBAT. Genes and proteins involved in glucose metabolism were upregulated with exercise in ingWAT, and decreased in iBAT, anterior subcutaneous WAT (asWAT), and retroperitoneal WAT (rpWAT). Exercise increased genes and proteins involved in fatty acid oxidation in pgWAT, iBAT, asWAT, cervical BAT (cBAT) and perirenal WAT (prWAT). These data indicate that each adipose tissue depot has a unique response to exercise. Identifying the depot specific adaptations to adipose tissue in response to exercise is essential to determine how adipose tissue contributes to the overall beneficial effect of exercise.Support or Funding InformationNational Institutes of Health Grants R01‐HL138738 and K01‐DK105109This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

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