Abstract
Conjugation is a generally accepted prerequisite for biliary excretion of bilirubin, but small amounts of unconjugated bilirubin regularly are identifiable in bile. This unconjugated pigment fraction usually is present in the bile together with much larger amounts of conjugated bilirubin suggesting a relationship in excretion between these two pigment types. Data are presented which suggest that the biliary excretion of unconjugated bilirubin is enhanced approximately 30-fold by the concomitant forced excretion of conjugated pigment in Gunn rats. Complex formation between the two pigment types (“bilirubin monoglucuronide”) is postulated to explain this phenomenon.
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