Abstract
The literature concerning the excretion of ascorbic acid is reviewed and discussed. Experiments have been carried out and results are given, to show the extent of the marked hourly variations which occur in the excretion of ascorbic acid by the kidneys. This variation is present at all physiological ascorbic acid blood levels and is not related to the urine pH nor to the urine rate of flow. The relationship of these findings to previous conceptions of ascorbic acid excretion is discussed. The controlling influence of tubular re-absorption in determining the rate of ascorbic acid excretion at normal blood levels is pointed out. We wish to thank the Medical Research Council of Ireland for the grant which made this work possible.
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