Abstract
In all of 10 cases with PHP (3 adults, 3 adolescents and 4 children from 5 families) intravenous TRH evoked excessive plasma thyrotropin responses as seen in mild primary hypothyroidism. A similar response was found in 4 among 6 cases with HP (1 adolescent and 5 children from 5 families). In none except 2 cases were clinical signs or other laboratory data suggestive of hypothyroidism. The diagnosis of PHP or HP was ascertained by the determination of immunoreactive serum parathyroid hormone and/or of urinary cyclic adenosine 3' 5' -monophosphate after intravenous infusion of parathyroid extract. TRH did not induce significant changes of serum parathyroid hormone concentration in any of 8 cases (6PHP, 2HP) tested.
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