Abstract
Lysine and arginine supplements were fed to 5-day-old chicks to test whether they would develop hypercholesterolemia in response to excess lysine in a fashion similar to mammals. Chicks developed hypercholesterolemia with a 4-5% lysine but not with arginine supplementation. These results indicate the lysine induced hypercholesterolemia is not due to anaplerotic interactions of arginine and lysine with the urea cycle.
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