Abstract
The association of endemic goitre with 'hard water' has been recognized for many years (see Murray, Ryle, Simpson & Wilson, 1948). Since radioactive iodine is such a useful tool in the investigation of thyroid physiology it is surprising that the effects of calcium on the function of the normal thyroid gland in man have not been studied with isotopic techniques. Studies of thyroid function with 132I on volunteers with dietary calcium supplements during 6 weeks are therefore reported. Six euthyroid subjects without a goitre were investigated. Five received 1·9 g. calcium daily in five divided doses as effervescent Calcium Sandoz tablets dissolved in 100 ml. tap water. Each tablet contains 4 g. calcium gluconate (equivalent to 0·38 g. calcium) and 20 mg. ascorbic acid. The sixth subject received placebo tablets which did not contain calcium. The thyroidal uptake of radioactive iodine 2½ hr. after an oral dose of 25
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