Examination of hemorheological and exerkine concentrations at four-week whole body vibration exercise in obese women: A pilot study.

A randomized controlled trial was conducted to clarify the beneficial effect of whole body vibration (WBV) exercise plus squat training on body balance, muscle power, and walking ability in the elderly with knee osteoarthritis and/or spondylosis. Of 35 ambulatory patients (14 men and 21 women) who were recruited at our outpatient clinic, 28 (80.0%, 12 men and 16 women) participated in the trial. The subjects (mean age 72.4 years) were randomly divided into two groups (n=14 in each group), ie, a WBV exercise alone group and a WBV exercise plus squat training group. A 4-minute WBV exercise (frequency 20 Hz) was performed 2 days per week in both groups; squat training (20 times per minute) was added during the 4-minute WBV training session in the WBV exercise plus squat training group. The duration of the trial was 6 months. The exercise and training program was safe and well tolerated. WBV exercise alone improved indices of body balance and walking velocity from baseline values. However, WBV exercise plus squat training was more effective for improving tandem gait step number and chair-rising time compared with WBV exercise alone. These results suggest the benefit and safety of WBV exercise plus squat training for improving physical function in terms of body balance and muscle power in the elderly.

BackgroundKnee osteoarthritis (KOA) is a leading cause of public disability. Neuromuscular function contributes to the development and/or progression of KOA. Whole body vibration (WBV) exercise improve the neuromuscular function of patients with neurological disorders and even that of older patients with limited exercise options. Therefore, WBV exercise may offer an efficient and alternative treatment for individuals with KOA. However, the effects of WBV training on the neuromuscular function of individuals with KOA remain unclear. Therefore, this study attempts to investigate the effect of a 12-week WBV exercise on the neuromuscular function of individuals with KOA.Methods/designWe will conduct a prospective, single-blind randomized controlled trial on 180 KOA patients. Participants will be randomly assigned to the WBV exercise, lower extremity resistance training, and health education groups. The WBV exercise group will participate in a 12-week WBV training. The lower extremity resistance training group will undergo a 12-week lower extremity resistance training of both lower limbs. The control group will receive health education for 12 weeks. After the intervention, the participants will be followed up for 3 months with no active intervention. Primary outcome measures will include anthropometric measurements, gait analysis during walking and stair climbing, muscle strength test of the knee and ankle, proprioception test of the knee and ankle, and neuromuscular response of the leg muscles. Secondary outcome measures will include self-reported pain and physical functional capacity, and physical performance measures. Furthermore, adverse events will be recorded and analyzed. If any participant withdraws from the trial, intention-to-treat analysis will be performed.DiscussionImportant features of this trial mainly include intervention setting, outcome measure selection, and study duration. This study is intended for estimating the effect of WBV intervention on neuromuscular control outcomes. Study results may provide evidence to support the beneficial effects of WBV exercise on the physical performance and neuromuscular control of individuals with KOA to fill the research gap on the efficacy of WBV.Trial registrationChinese Clinical Trial Registry, ID: ChiCTR-IOR-16009234. Registered on 21 September 2016.

Vibration is a mechanical stimulus that is characterized by an oscillatory motion. When there is a direct contact of a person, in general standing on the base of this type of platform, the vibration that is produced in these machines is transmitted to the body of the subject producing whole body vibration (WBV) exercises. Biological effects can be associated with the WBV exercises with desirable and undesirable consequences. These effects of the WBV exercises seem to be related to a direct effect in a tissue/organ/system and/or or to indirect effects due to alteration of the plasma concentration of some hormonal and non hormonal biomarkers. The aim of this investigation is to present a revision about hormonal and non hormonal biomarkers in human beings submitted to WBV exercises that have suffered alteration in the plasma concentrations. Searches were performed in the PubMed and Scopus databases with the key words “whole body vibration”. Papers were selected following defined criteria. Considering the WBV exercise, hormonal fluctuations of testosterone, growth, insulin-like growth factor1, epinephrine, norepinephrine, cortisol, irisin, parathyroid hormone and sclerotin are observed. Non hormonal biomarkers have suffered alterations in response to WBV, as glucose, free fatty acids, adiponectin, transforming growth factor-beta1, nitric oxide, osteopontin, interleukin-1beta, bone-specific alkaline phosphatase, cartilage oligometric matrix protein and tumor necrosis factor-alpha in plasma concentration. In conclusion, putting together the findings related to the alterations of the concentration of hormonal and non hormonal biomarkers due to the WBV exercises, it is possible that the fluctuations in the plasma concentrations of these biomarkers might help us understand better the biological effects of this kind of exercises, probably due to neuroendrocrine responses.   Key words: Whole body vibration exercise, vibration, hormonal and non hormonal fluctuations &nbsp

PURPOSE: This study aimed to investigate the effects of 8 weeks of moderate-intensity aerobic exercise on body composition and serum irisin and leptin levels in obese women.METHODS: Obese women in their 20s were divided into an aerobic exercise group (AEG; n=8) and a control group (CON; n=8). Aerobic exercise was conducted at an intensity of 65-70% of the maximal oxygen uptake, with a target energy expenditure of approximately 1,000 kcal/week (350 kcal/session) to promote health. To assess the effects of exercise, body weight and body fat percentage were measured before and after the intervention. Blood samples were collected to analyze serum irisin and leptin levels.RESULTS: The aerobic exercise group achieved a reduction in body weight and body fat percentage and exhibited increased serum irisin levels. Conversely, serum leptin levels were seen to decrease.CONCLUSIONS: This study confirmed that moderate-intensity aerobic exercise is effective in reducing body weight and body fat in obese individuals and positively influences serum irisin and leptin levels. Furthermore, these findings provide a basis for establishing exercise volume during workouts, highlighting the significance of these experimental results.

Background: Low back pain is pain due to disc pressure on the nerves that come out through the gap between the vertebrae. Heavy equipment operators have a high risk of developing LBP due to prolonged sitting and vibrations from the machine. This will result in injury and also stiffness in the joints and spine. This study aims to analyze the effect of stretching and whole-body vibration exercise on reducing low back pain in heavy equipment operators/workers. Subjects and Method : This is a meta-analytical study and a systematic review. The articles used were obtained from several electronic databases including Google Scholar, PubMed, Springer Link, Clinical key and ProQuest. The articles used in this study are articles that have been published from 2011-2021. The keywords used in the search were “stretching and low back pain”, “stretching and whole body vibration exercise”, “stretching and low back pain, “stretching or whole body vibration exercise or low back pain”, “stretching or whole body vibration exercise". The article under study is a full text article with a Randomized Controlled Trial (RCT) design, a measure of the relationship used with Mean SD. Articles were collected using the PRISMA diagram, and analyzed using the Review Manager 5.4 . application. Results: Stretching (SMD -0.47; 95% CI=-0.96 to 0.02; p=0.06) and Whole Body Vibration Exercise (SMD -0.37; 95% CI= -0.72 to -0.02; p=0.04) has an effect on reducing Low Back Pain. Conclusion: Stretching exercises and Whole Body Vibration can reduce and decrease lower back pain after getting the intervention. Keywords: Stretching, Low Back Pain, Whole Body Vibration Exercise Correspondence: Melinda Febianca Gaurinindi. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: melindafebiancaa@gmail.com Mobile: 08996063587. Journal of Epidemiology and Public Health (2021), 06(04): 426-437 https://doi.org/10.26911/jepublichealth.2021.06.04.04

Vibrations produced in oscillating/vibratory platform generate whole body vibration (WBV) exercises, which are important in sports, as well as in treating diseases, promoting rehabilitation, and improving the quality of life. WBV exercises relevantly increase the muscle strength, muscle power, and the bone mineral density, as well as improving the postural control, the balance, and the gait. An important number of publications are found in the PubMed database with the keyword “flexibility” and eight of the analyzed papers involving WBV and flexibility reached a level of evidence II. The biggest distance between the third finger of the hand to the floor (DBTFF) of a patient with metabolic syndrome (MS) was found before the first session and was considered to be 100%. The percentages to the other measurements in the different sessions were determined to be related to the 100%. It is possible to see an immediate improvement after each session with a decrease of the %DBTFF. As the presence of MS is associated with poorer physical performance, a simple and safe protocol using WBV exercises promoted an improvement of the flexibility in a patient with MS.

The purpose of this systematic review was to investigate the effects of whole body vibration (WBV) exercise in the management of cancer therapy-related morbidities. The PubMED and PEDro databases were used to access publications published in English about the use of whole body vibration (WBV) exercises in cancer patients until February 22nd 2017. The studies included were classified according to the level of evidence (LE) by the National Health and Medical Research Council Hierarchy of evidence and the methodological quality (MQ) by the PEDro scale. The four included studies (2 of them with "high" LE-II and MQ) were performed in patients with different types of cancer (i.e. breast, lung, prostate, solid or hematological), treated with WBV exercise to counteract the cancer therapy-related morbidities. The variables evaluated were muscle activity, subjective rate of perceived exertion, exercise capacity, muscle strength, quality of life, resting urinary incontinence and severity of peripheral neuropathy. Although WBV exercise appears to be a potential treatment procedure of cancer therapy-related morbidities, further additional studies are required to determine specific and tailored protocols to be used in the different stages of the disease.

Effect of whole body vibration exercise on muscle strength and proprioception in females with knee osteoarthritis

PurposeExercise on a whole body vibration (WBV) platform, namely WBV exercise (WBVE), has long-term beneficial effects on glucose metabolism, similarly to conventional moderate-intensity exercise. Conventional moderate-intensity exercise reduces post-load plasma glucose levels at the acute phase. This study aimed to reveal acute effects of WBVE on post-load glucose metabolism.MethodsThis randomized crossover trial enrolled 18 healthy men. They completed the following three interventions in a random order: (1) a 2-hour 75-g oral glucose tolerance test (OGTT) without WBVE (OGTT-alone), (2) 20-minute WBVE before an OGTT (WBVE → OGTT), and (3) 20-minute WBVE during an OGTT (OGTT → WBVE). Post-load glucose metabolism in the WBVE → OGTT and OGTT → WBVE interventions were compared with that in the OGTT-alone intervention.ResultsPlasma glucose levels in the WBVE → OGTT and OGTT → WBVE interventions were not significantly different from those in the OGTT-alone intervention at any time point except 15 min, wherein the WBVE → OGTT intervention had higher glucose levels (111 [interquartile range, 102–122] mg/dL vs 122 [111–134] mg/dL, P = 0.026). Higher plasma glucagon levels were observed at 0 min in the WBVE → OGTT intervention and at 60 min in the OGTT → WBVE intervention (P = 0.010 and 0.015). Cortisol, Growth hormone, and adrenaline levels were significantly increased after WBVE, whereas noradrenaline levels were not. Serum insulin levels in the WBVE → OGTT intervention were significantly higher than those in the OGTT-alone intervention at 0 min (P = 0.008).ConclusionsWBVE did not decrease post-load plasma glucose levels at the acute phase. Acute effects of WBVE on post-load glucose metabolism would not be identical to those of conventional exercise.The unique trial number and the name of the registry: UMIN000036520, www.umin.ac.jp, date of registration, June 12, 2019.

Sarcopenia in patients with cancer makes patients physically weak and adversely affects their compliance with treatment. In this study, we investigated the relationship between sarcopenia in patients with cancer and circulating irisin and tumor necrosis factor-alpha (TNF-α) levels. A total of 141 patients with different types of newly diagnosed cancer were divided into two groups, sarcopenia (n = 72) and non-sarcopenia (n = 69) groups. The body compositions of the patients were measured using bioelectrical impedance (BIA) and muscle strength using hand grip strength (HGS) tests. Serum irisin and TNF-α levels were measured using an enzyme-linked immunosorbent assay. In our study, serum irisin levels were found to be significantly lower (p < 0.01) and TNF-α levels were found to be significantly higher (p = 0.014) in the sarcopenia group. Skeletal muscle index (SMI) and HGS values and serum irisin levels were positively correlated [(r: 0.451, p < 0.001), (r: 0.469, p < 0.001)], and SMI and HGS values and serum TNF-α levels were negatively correlated [(r: -0.181, p = 0.032) and (r: -0.143, p = 0.090), respectively]. In addition, multiple linear regression analysis showed that serum irisin and TNF-α levels were independent predictors of sarcopenia. Serum irisin levels were found to be significantly lower in patients with cancer with sarcopenia, and TNF-α levels were found to be significantly higher. These two markers can be used as potential biomarkers for the diagnosis of sarcopenia in patients with cancer. The efficacy and possible mechanisms of action of irisin and TNF-α in the diagnosis of sarcopenia should be investigated with larger patient groups.

In recent years, the effect of vibration applications on the endocrine system is a subject which has been discussed. Studies have shown that muscle contractions cause some responses in the endocrine system. This study aimed to determine the effects of whole body vibration (WBV) exercise applied at different environmental temperatures on the distribution of the irisin in muscle tissue. In our study, 30 healthy and adult female rats were used. Rats were divided into four groups as a control group (n = 6) and three different experimental groups (n = 8). 1st experimental group at 15 ± 0.5˚C, 2nd experimental group in normal room conditions, 3rd the experimental group at 35 ± 0.5˚C applied WBV exercise 5 sessions a week, 20 minutes in each session for 4 weeks. The control group rats were kept in vibration cassettes at normal room temperature, with the same number and duration of sessions, without WBV exercise. After all experimental procedures were completed, samples of skeletal muscle (M.gastrocnemius) tissue taken from the rats in the groups were used as material. When the localization and distribution of irisin in the skeletal muscle tissue were examined, it was determined that irisin was secreted from both muscle fibers and connective tissue in all groups, and the concentration of irisin synthesized from muscle fiber was the highest in the 3rd experimental group (p &lt; 0.05). As a result, in this study, WBV exercise applied in a hot environment increases the level of irisin in muscle tissue more than WBV exercise applied in a cold environment and at room temperature.

Quality of life (QoL) is one of the most important health outcome concepts expressed subjectively. Chronic pain (CP) is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Taking into account the poor QoL and the CP already described in metabolic syndrome (MSy) individuals, this study aimed to evaluate the effects of whole body vibration exercises (WBVE) on these parameters in this population. Thirty-three MSy patients were divided in subgroups A [whole body vibration exercise group (WBVeG), n = 17, 15 females/2 males, 61.1 ± 8.4 yr] and B (control group, n = 16, 14 females/2 males, 58.2 ± 9.1 yr). Subgroup A performed 10 sessions (2 times/wk) of WBVE (18 min/session, with a frequency from 5 up to 14 Hz and a peak-to-peak displacement of 2.5, 5.0, and 7.5 mm) on a side-alternating vibrating platform (VP). Subgroup B did the same protocol, but the VP was turned off. The individuals answered the World Health Organization Quality of Life bref (WHOQoL-bref) questionnaire before the first and after the 10th session. The chronic pain level (CPL) was measured by a numeric rating scale (0-10) before and at the end of each session. Significant improvements were found in physical health (P = 0.05) and psychological health (P = 0.04) domains of WHOQoL-bref in WBVeG. A significant acute reduction of the CPL was found in the WBVeG after the protocol, considering the first session and at the last session. WBVE marginally improved physical health and psychological health and decrease the CPL in acute interventions.NEW & NOTEWORTHY Metabolic syndrome patients experience poor quality of life, frequently associated with lack of exercise and bad dietary habits. Additionally, factors such as obesity, neuromusculoskeletal impairment, and peripheral endothelial dysfunction result in a chronic pain level. Whole body vibration exercise might represent a suitable physical therapy, since it is easy to perform, low cost, safe, and capable of promoting an improvement of quality of life and reducing chronic pain level during acute interventions in metabolic syndrome individuals.

The aim of our study was to determine whether adipocyte-derived hormones leptin, adiponectin and resistin contribute to the improvement of insulin sensitivity after very-low calorie diet (VLCD). Therefore, serum levels of these hormones were measured in fourteen obese females before and after three weeks VLCD and in seventeen age- and sex-matched healthy controls. Body mass index, HOMA index, serum insulin and leptin levels in obese women before VLCD were significantly higher than in control group (BMI 48.01+/-2.02 vs. 21.38+/-0.42 kg/m(2), HOMA 10.72+/-2.03 vs. 4.69+/-0.42, insulin 38.63+/-5.10 vs. 18.76+/-1.90 microIU/ml, leptin 77.87+/-8.98 vs. 8.82+/-1.52 ng/ml). In contrast, serum adiponectin and soluble leptin receptors levels were significantly lower in obese women before VLCD than in the control group. No differences were found in serum glucose and resistin levels between the obese group before VLCD and the control group. VLCD significantly decreased BMI, HOMA index, serum glucose, insulin and leptin levels and increased soluble leptin receptor levels. The changes in serum adiponectin and resistin levels in obese women after VLCD did not reach statistical significance. We conclude that leptin and soluble leptin receptor levels were affected by VLCD while adiponectin and resistin concentrations were not. Therefore, other mechanisms rather than changes in the endocrine function of the adipose tissue are probably involved in the VLCD-induced improvement of insulin sensitivity.

The link between serum irisin levels and body fat markers has long been questioned in adult populations. However, there is scant research specifically addressing this link in obese female individuals. This study will thoroughly evaluate the relationship between serum irisin levels and adiposity indices in an obese female population. The study involved a group of 40 women, aged between 20 and 24 years, who were experiencing obesity. The correlations of serum irisin with adiposity markers measurements were determined. The statistical evaluation was conducted using a parametric linear correlation approach. Serum irisin levels, quantified in ng/mL, positively correlated with several adiposity indicators. Notably, there was a meaningful relationship with body weight in kilograms (r = 0.385, p = 0.014), body mass index (BMI) (r = 0.588, p ≤ 0.001), body fat percentage (r = 0.450, p = 0.004), total fat mass in kilograms (r = 0.342, p = 0.031), and lean body mass in kilograms (r = 0.344, p = 0.029). Furthermore, waist circumference in centimeters (r = 0.329, p = 0.038), hip circumference in centimeters (r = 0.321, p = 0.043), and the waist-to-hip ratio (r = 0.447, p = 0.004) also demonstrated positive correlations with irisin concentrations. Conversely, body height in meters showed no significant correlation (r = -0.003, p ≥ 0.05). Serum irisin’s relationship with adiposity markers is evident, yet it does not extend to body height. Interrelationships among adiposity markers might influence serum irisin in obese women after single-session exercise. Keywords: Serum irisin, adiposity markers, female, obesity.

Introduction: Chronic obstructive pulmonary disease (COPD) is a chronic disease related to various systemic manifestations including dyspnea, exercise intolerance and peripheral muscular dysfunction, with a direct impact on functional capacity. Objectives: To verify if whole body vibration exercises (WBVE) can be used as exercise modality in individuals with COPD without leading to exacerbation of the disease, with several clinical benefits. Methods: Individuals diagnosed with COPD, aged ≥ 40 years, will be randomly distributed into 4 groups: control group (CG) who will not undergo WBVE, with their normal daily routine, group who will be exposed to WBVE in the sitting position in an auxiliary chair once a week (GS1) and twice a week (GS2) and WBVE group twice a week in the standing position with knee flexion (GP2). The protocol will last 6 weeks, each session will have 5 sets of 1 min vibration with 1 min rest, frequency 25 Hz and peak-to-peak displacement 2.5 mm. Muscle strength and function will be assessed through manual dynamometry and surface electromyography and dyspnea using the Modified Borg Scale (MBS) and the Medical Research Council (MRC) Scale. Discussion: WBVE, due to the various effects already described, seem to be a promising exercise modality for individuals with COPD, potentially being used as an instrument for pulmonary rehabilitation. Conclusions: The results of this study may provide evidence to justify a WBVE program to the improvement on the physical performance and on neuromuscular function of individuals with COPD.Keywords: COPD; Whole-body vibration exercise; Muscular function; Pulmonary rehabilitation.