Abstract
Appreciable phospholipase A 2 activity was detected in a hind paw homogenate from rats with adjuvant arthritis or carrageenan-induced edema. The activity was neutralized by treatment with antibody raised against rat platelet secretory phospholipase A 2, indicating that 14-kDa group II phospholipase A 2, was induced in the hind paw during the process of inflammation. Injection of purified rat platelet phospholipase A 2 into the hind paw of rats with adjuvant-induced arthritis resulted in exacerbation of edema in a dose-dependent manner, whereas no effect was observed on either normal rats or animals with carrageenan-induced edema under the same experimental conditions. These results suggest the importance of mammalian group II phospholipase A 2, in the pathogenesis of some types of inflammation.
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