Evidence for the Renal Origin of the Malignant Phase of Essential Hypertension.

Abstract

Meeting Abstracts1 May 1970Evidence for the Renal Origin of the Malignant Phase of Essential Hypertension.Gaddo Onesti, M.D., Kwan Eun Kim, M.D., (Associate), Albert N. Brest, M.D., F.A.C.P., Charles Swartz, M.D., F.A.C.P.Gaddo Onesti, M.D.Search for more papers by this author, Kwan Eun Kim, M.D., (Associate)Search for more papers by this author, Albert N. Brest, M.D., F.A.C.P.Search for more papers by this author, Charles Swartz, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-802_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSix uremic patients with malignant phase of essential hypertension were studied before and after bilateral nephrectomy. All patients had documented essential hypertension for 2 to 10 years. Histologic examination of all kidneys demonstrated malignant nephrosclerosis but no primary renal parenchymal disease or renal artery stenosis. The following values were measured twice a week before and after nephrectomy for 6 to 16 months: intra-arterial pressure, cardiac output, total peripheral resistance, blood volume, total exchangeable sodium, peripheral plasma renin. Diastolic blood pressure averaged 158 mm Hg before nephrectomy and 93 mm Hg after nephrectomy. The decrease in blood pressure after nephrectomy was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 802-802KeywordsBlood pressureBlood volumeCardiac outputHypertensionKidneysNephrectomyRenal arteriesRenal diseasesSodiumStenosis Issue Published: 1 May 1970 PDF DownloadLoading ...