Abstract
Acid extracts of cysts and newly hatched nauplii of Artemia salina contain large amounts of guanine derivatives but only very small amounts of adenine compounds. As the nauplii undergo further differentiation, the total purine concentration remains constant, but the total adenine concentration increases. The increase in total adenine equals the decrease in total guanine. Since the nauplii are incapable of synthesizing purines de novo, a direct conversion of guanine compounds to adenine compounds must occur. Furthermore, P1,P4-diguanosine 5'-tetraphosphate appears to serve as a direct precursor of adenosine triphosphate, its guanine moiety being converted to adenine and its pyrophosphate bonds being conserved in the transition. The other guanine-containing compounds of the acid-soluble pool appear to serve as a source of nucleic acid guanine.
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