Abstract
There is great excitement in the tuberculosis (TB) scientific community over the introduction of new tools into TB control activities. The development of new tools is an important component of the Global Plan to Stop TB and the World Health Organization's new global Stop TB Strategy [1,2]. Anticipating the introduction of new tools, the Stop TB Partnership has established a Retooling Task Force to develop a framework for engaging policy makers to foster accelerated adoption and implementation of new tools into TB control programs [3].
Highlights
There is great excitement in the tuberculosis (TB) scientific community over the introduction of new tools into TB control activities
A key challenge is to maintain the momentum gained in the past few years, and expand the scope and role of evidence synthesis to outcomes that go beyond conventional diagnostic accuracy
The GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to grading the quality of evidence and strength of recommendations for diagnostic tests recognizes that diagnostic accuracy results are surrogates for patientcentered outcomes, and emphasizes that diagnostic tests are of value only if they result in improved outcomes for patients [61]
Summary
The need to formulate new or revised policies may arise from WHO’s ongoing monitoring of technical developments or from interested parties submitting requests with supporting documentation for policy or guideline development. To consider a global policy change, WHO must have solid evidence, including clinical trials or field evaluations in high TB prevalence settings
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