Abstract
Evaluation The Effect of Folic Acid on Some Inflammatory Mediators; IL-6 and TNF-α in Chronic Gingivitis Patients
Highlights
Periodontal disease is highly prevalent in world population[1]
The results are showing that there is no significant difference in gingival index (GI) and oral hygiene index (OHI) between treatment group and control group at the beginning of the study by using Independent T-test of two means.(Table 1)
At the beginning of study, the results showed that there are no significant changes in the level of salivary IL
Summary
Periodontal disease is highly prevalent in world population[1]. Gingivitis is a form of periodontal disease in which gingival tissues are inflamed but their destruction is mild and reversible. Gingival inflammation is caused by a pathogenic infection which triggers the innate immune system[2,3] causing inflammation and oxidative stress in the oral tissues. It is a reversible disease in which the gum becomes red, swollen and bleed while touching, or brushing. Stimulation of pro-inflammatory cytokines as IL-6 and TNF-α will participate as an integral part of periodontal disease pathogenesis[6,7]. These inflammatory cytokines are detectable in oral fluids[8,9]. This study is hypothesized that folic acid supplementation might be associated with gingival inflammation improvement and to evaluate its effect on some inflammatory mediators; IL-6 and TNFα in the saliva
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