Evaluation on short-term efficacy of cervus and cucumis polypeptide injection in treatment of ankylosing spondylitis

Abstract

Objective To evaluate the short-term efficacy and safety of cervus and cucumis polypeptide injection(CCPI) in treatment of ankylosing spondylitis(AS).Methods 108 patients with AS were randomized into two groups :54 patients took NSAIDs and leflunomide (LEF) (control group),and 54 patients were treated with NSAIDs,LEF and CCPI(test group).The treatment was lasted for three weeks.The observation included the prevalence of low back pain,time of morning stiffness,Bath AS disease activity index (BASDAI),Bath AS functional index (BASFI) ,ESR,C-reactive protein(CRP) and side effects.SPSS16.0 statistics software was used to analyze the data.Results After treatment for three weeks,the prevalence of low back pain,the time of morning stiffness,BASDAI,BASFI,ESR and CRP were significantly lower than those at administration (P ＜ 0.05),and there were no table differences between the two groups too,(P ＜ 0.05).Gastrointestinal symptoms were the main side effects,but there were no significance between the two groups.Conclusion CCPI is an effective medicine in the treatment of AS,which could modify the disease activities,and its side effect is mild.It is suggested that CCPI can be used as an adjuvant medication in the treatment of AS. Key words: Spondylitis; Ankylosing; Cervus and cucumis polypeptide injection; Leflunomide