Abstract
In recent years, using of plants to develop combine therapies for treatment of certain diseases such as cancer, Alzheimer's disease, and diabetes mellitus is extremely plausible approach. Perhaps, the definitive treatment of some of these diseases is hidden in the complex content of a plant in nature. Thus, in the present study, we decided to determine the biological activities of methanol and water extracts of the endemic Sideritis libanotica. To the best of our knowledge, the present study is the first investigation on antioxidant, enzyme inhibitory activity, antimicrobial activity, and in vitro cytotoxicity of S. libanotica. According to results, while the methanol extract shows better anti-cholinesterase, α-glucosidase, and α-amylase inhibition activity and cytotoxicity than the water extract, the tyrosinase inhibitory activity of the water extract was found to be better than the methanol extract. This study provides valuable information on how the biological activity of endemic S. libanotica changes in different solvent extractions such as water and methanol.
Highlights
Sideritis species have been widely utilized against gastrointestinal disorders and common colds in folk medicine
Sideritis species rich in essential oil, terpenes and flavonoids have been widely consumed for centuries to relieve cold symptoms, including fever, flu, sore throat, bronchitis, and to treat of gastrointestinal disorders such as stomach ache, indigestion and flatulence (Schmeda-Hirschmann and Yesilada, 2005; González Burgos et al, 2011; Korkmaz et al, 2017a; Korkmaz et al, 2017b;) It has been reported that some Sideritis species such as S. lycia and S. libanotica are feared to be in the list of endangered species because of their extensively collection from natural habitat (Kargioglu et al, 2008; Polat and Satil, 2012; Dincer et al, 2017)
Our results revealed that the water extract showed a good tyrosinase inhibitory activity than the methanol extract, it was higher than the kojic acid which was used as a positive control showed an inhibition level of 56.42%
Summary
Sideritis species have been widely utilized against gastrointestinal disorders and common colds in folk medicine. Sideritis species rich in essential oil, terpenes and flavonoids have been widely consumed for centuries to relieve cold symptoms, including fever, flu, sore throat, bronchitis, and to treat of gastrointestinal disorders such as stomach ache, indigestion and flatulence (Schmeda-Hirschmann and Yesilada, 2005; González Burgos et al, 2011; Korkmaz et al, 2017a; Korkmaz et al, 2017b;) It has been reported that some Sideritis species such as S. lycia and S. libanotica are feared to be in the list of endangered species because of their extensively collection from natural habitat (Kargioglu et al, 2008; Polat and Satil, 2012; Dincer et al, 2017). Natural antioxidants especially exist in plants have been extensively studied owing to their beneficial effects on human health. Besides these effects, antioxidants are able to Received: 12 Mar 2019.
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