Abstract
Evaluation of Ultrasensitive C-Reactive Protein as a Cardiovascular Risk Marker in Pediatric Patients with End-Stage Renal Disease on Peritoneal Dialysis
Highlights
Patients with End-Stage Renal Disease (ESRD) are at elevated risk for morbidity and mortality due to cardiovascular disease [1,2]
Ultrasensitive C-Reactive Protein (USCRP) could be superior to other Risk Factors (RF) in detecting the damage
As compared to the general population, adverse cardiac events occur at rates 30 times higher in patients with End-Stage Renal Disease (ESRD) and 700 times higher in patients on renal replacement therapy (Peritoneal Dialysis (PD) or hemodialysis), with a concomitant 10-year decrease in life expectancy 10 years after diagnosis [3,4,5,6]
Summary
Patients with End-Stage Renal Disease (ESRD) are at elevated risk for morbidity and mortality due to cardiovascular disease [1,2]. The main cardiovascular complications found in pediatric ESRD patients include left ventricular abnormalities (initially hypertrophic and dilated cardiomyopathy); arrhythmias; pericardial complications (pericarditis and tamponade); and abnormalities indicative of early atherosclerosis, such as thickening of the carotid intimae, and endothelial dysfunction, as measured by brachial artery flow [7,8,9,10]. Patients with End-Stage Renal Disease (ESRD) on Peritoneal Dialysis (PD) experience high morbidity and mortality due to Cardiovascular (CV) disease. The objective was to assess CV risk in pediatric patients with ESRD on PD and evaluate the utility of USCRP as a CV risk marker
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