Abstract
In a group of 42 unipolar depressed patients with melancholia the thyrotropin (TSH) and prolactin (PRL) responses to TRH were studied in relation to the clinical response to an ECT course. Patients were categorized as responders or nonresponders using as criterion a 50% reduction in the Hamilton Rating Scale for Depression score. Comparison between responders and nonresponders with respect to the TSH and PRL responses to TRH did not reveal any significant differences. Thus, TSH and PRL responses were not proved to have a predictive value for the therapeutic ECT response in melancholia.
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