Abstract
Evaluation of tolonium chloride as an aid in diagnosis of dysplastic changes in oral mucosa among tobacco smokers - JOOO- Print ISSN No: - 2395-6186 Online ISSN No:- 2395-6194 Article DOI No:- 10.18231/j.jooo.2020.025, Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology-J Oral Med Oral Surg Oral P
Highlights
Most cases of oral cancer are associated with habits and are preceded by asymptomatic clinical lesions collectively referred to as oral potentially malignant disorder.[1]
OPMD is a clinical diagnosis for which the histological diagnosis may be hyperplasia, hyperkeratosis, oral epithelial dysplasia (OED) or oral squamous cell carcinoma (OSCC)
This study was undertaken to define the clinical utility of Tolonium chloride as a diagnostic aid amongst high-risk patients i.e. patients with tobacco smoking habit, to identify potential areas that might proceed into cancer and which are not otherwise identified during clinical examination and guide to select the biopsy site
Summary
Most cases of oral cancer are associated with habits and are preceded by asymptomatic clinical lesions collectively referred to as oral potentially malignant disorder.[1]. To evaluate the clinical utility of Tolonium chloride as a diagnostic aid amongst high-risk patients i.e. patients with tobacco smoking habit, to identify potential areas that might proceed into cancer and which are not otherwise identified during clinical examination and guide to select the biopsy site. Results: The results of the present study showed sensitivity and specificity of 56.34% and 50.56% respectively for the Tolonium chloride mouth rinse to be used as a routine screening agent in detecting premalignant areas in otherwise apparent normal oral mucosa in high-risk group of people. Conclusion: Tolonium chloride rinse is more sensitive as compared to the clinical examination alone, in detecting dysplastic changes in clinically apparent normal oral mucosa, among tobacco smokers. The procedure cannot be performed on routine basis for high-risk group of people
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