Abstract
Thrombocytopenia is a physiological deficiency in platelet counting. Fragmented RBC can be a chronic trigger for a subclinical micro angiopathy that results in chronic consumption of platelets. The platelet is a small, lentiform, anucleated cell that play a vital role in hemostasis and are produced in the bone marrow from megakaryocytes. To evaluate different etiological factors of thrombocytopenia by the study of clinical profile and laboratory parameters in patients with thrombocytopenia carried out in Sree Balaji Medical College and Hospital, Chennai. After evaluating all cases of thrombocytopenia, it is concluded that infective causes are more common than non-infective causes. Infections like dengue, malaria and septicemia were the common causes of thrombocytopenia along with megaloblastic anemia. Whenever thrombocytopenia is detected, a further investigation has to be done for specific diagnosis in the most of the cases so that appropriate treatment can be given.
Highlights
The definition of thrombocytopenia is platelet count < 1.5 lakhs/chum. It is the commonest platelet abnormality observed in clinical practice with different clinical expression
Numerous mechanisms may contribute in development of thrombocytopenia as seen in primary immune thrombocytopenia & hepatitis C virus infection
The present study focuses on the evaluation of thrombocytopenia in different age groups who were established with thrombocytopenia
Summary
The definition of thrombocytopenia is platelet count < 1.5 lakhs/chum It is the commonest platelet abnormality observed in clinical practice with different clinical expression. It may result from either decreased production or increased sequestration/destruction of platelets. Platelet production involves aggregation of components within the cell cytoplasm, segregation within a demarcation membrane system and organization into proplatelets [3]. Platelets escaped identification for a long time, because of their small size and the limited resolution of early microscopes, in 1735, the German physician and poet Paul Gottlieb Werlhof provided the first detailed description of ‘morbus maculosus haemorrhagicus’ known as immune thrombocytopenia (ITP), these blood cells were unknown [10,11]. The present study aimed to nalyse the associated causes for the development of thrombocytopenia in patients admitted to Sree Balaji Medical college and Hospital, Chennai
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