EVALUATION OF THE TREATMENT FOR NONPARASITIC LIVER CYSTS BY ONE-TIME INTRACYSTIC INSTILLATIONS OF MINOCYCLINE HYDROCHLORIDE AND CARBON DIOXIDE UNDER ULTRASONICALLY GUIDED PUNCTURE

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In the past 6 years 14 patients with large nonparasitic liver cysts were treated by intracystic instillation of minocycline hydrochloride or/and carbon dioxide under ultrasonically guided puncture. Six patients were treated with only minocycline hydrochloride and eight patients were treated with both minocycline hydrochloride and carbon dioxide. Four patients treated with minocycline hydrochloride experienced a shrinkage of cysts by more than 80%, but the remaining two showed a decrease in size by less than 70%. On the other hand, all eight patients treated with both minocycline hydrochloride and carbon dioxide obtained a shrinkage of cysts by more than 90%. There were no serious complications in this series, so safety and shortening of hospital stay by this method were confirmed. It is concluded that ultrasonically guided intracystic instillation of minocycline hydrochloride and carbon dioxide is more effective than their use singly. The treated cysts were reducing gradually and they finally obtained obvious shrinkage of the cysts. After all, we have to avoid premature evaluation of therapeutic efficacy, and therefore, have to follow up for at least a year without repeated injections.