Abstract
In 69 women with threatened abortion (TA), the outcome of the pregnancy was compared to the plasma concentration of progesterone, estradiol and human chorionic gonadotropin (HCG) in a peripheral blood sample which was taken as soon as the diagnosis of TA had been made. The assay of HCG gave a very good prediction of the outcome and low levels indicated an inevitable abortion. The assays of progesterone and estradiol both rendered a more uncertain prediction and did not add further information for the evaluation of the prognosis. These findings might be explained by the different sites of production of these hormones, since in early pregnancy progesterone and estradiol are produced in both the corpus luteum graviditatis and the placenta while HCG is produced only in the placenta.
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