Evaluation of the irritant effect of the drug Tildoks AVZ on the eye’s mucous membranes

Abstract

The purpose of our studies was to evaluate the irritating effect of Tildox AVZ on the mucous membranes of the eyes. Tildox AVZ is a combined antibiotic in the form of a powder, which contains 100 mg doxycycline hyclate and 100 mg tylosin tartrate as active ingredients per 1 g. During the research, 18 mature albino rabbits weighing 3.0 - 3.5 kg were involved. For this, 3 groups of rabbits were formed, 6 animals each. The study drug was administered to the animals in the conjunctival cavity of the right eye in the dose of 3 drops in 1, 3 and 5% concentrations. The left eye of each rabbit was used as a control. The reaction was taken into account immediately after the introduction of the drug into the conjunctival cavity and also in 30 minutes; 1, 4, 24, 48 and 72 hours; 7, 14 days and 21 days after application. The results showed that when Tildox AVZ was applied at different concentrations to the mucous membrane of the eye it did not have an irritating effect. The effect of eye treatment with the drug in all concentrations presented was absent. There were no such phenomena as: hyperemia of the conjunctiva, opacity of the cornea, swelling of the eyelids or discharge from the eyes. As a result of the studies it was found that a single injection of the drug Tildox AVZ into the conjunctival sac of rabbits at concentrations of 1, 3 and 5% does not cause a response, which indicates the absence of an irritating effect of the drug on eye tissues.