Abstract
The objective was to evaluate the in silico, in vitro and in vivo effects of a black bean hydrolyzed protein isolate (HPI) and its pure peptides on glucose absorption. By interacting with their protein motif, pure peptides blocked glucose transporters GLUT2 and SGLT1. HPI (10mg/mL) reduced formation of intracellular oxygen reactive species by 71%. Glucose absorption decreased 21.5% after 24h treatment when using the Caco-2 cell model. Oral glucose tolerance test in rats showed a 24.5% decrease on postprandial glucose (p<0.05) (50mg HPI /kg BW). In the hyperglycemic rat model, HPI caused a reduction of blood glucose, in a dose-dependent manner. The lowest fasting glucose was found in rats receiving 150 and 200mg/kg BW/day HPI, (p<0.05). The black bean HPI is an inexpensive food source of bioactive compounds that could be used in the management of blood glucose.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
