Abstract
Objective: The objective of the study was to evaluate the effect of Piper betle L. leaves extract against clonidine-induced catalepsy and milk-induced leukocytosis and eosinophilia in mice.
 Methods: Methanolic extract of P. betle L. leaves was prepared using Soxhlet apparatus. Preliminary phytochemical screening of the prepared extract was carried out using standard chemical tests. Effect of the prepared extract was evaluated against clonidine-induced catalepsy and milk-induced leukocytosis and eosinophilia in mice model.
 Results: Maximum duration of catalepsy was observed at 90 min after the clonidine administration. There was a significant inhibition (p˂0.05) of clonidine-induced catalepsy in the animals pretreated with chlorpheniramine maleate and extract of P. betle leaves. Administration of milk (4 mg/kg) subcutaneous route exhibited a significant increase in leucocytes and eosinophil count after 24 h of administration. Methanolic extract of P. betle L. leaves showed significant inhibition (p˂0.05) of milk-induced leukocytosis and eosinophilia.
 Conclusion: These results suggest that P. betle leaves extract may have the potential therapeutic value in the treatment of allergic diseases.
Highlights
Piper betle Linn. is a perennial dioecious climber, stems are semi-woody, much thickened at nodes; leaves large, 15–20 cm long, broadly ovate, slightly cordate, shortly acuminate, acute, entire, glabrous, yellowish or bright green, shining on both sides [1]
The primary goal of this research was to evaluate the effect of P. betle L. leaves extract against clonidine-induced catalepsy and milk-induced leukocytosis and eosinophilia in mice
Clonidine-induced catalepsy All the groups showed a maximum duration of catalepsy at 90 min after the clonidine administration
Summary
Piper betle Linn. is a perennial dioecious climber, stems are semi-woody, much thickened at nodes; leaves large, 15–20 cm long, broadly ovate, slightly cordate, shortly acuminate, acute, entire, glabrous, yellowish or bright green, shining on both sides [1]. Is a perennial dioecious climber, stems are semi-woody, much thickened at nodes; leaves large, 15–20 cm long, broadly ovate, slightly cordate, shortly acuminate, acute, entire, glabrous, yellowish or bright green, shining on both sides [1]. It is commonly known as the betle vine, it is an important medicinal and recreational plant [2]. The betle leaves are nutritive and possess antitumor [5], wound healing [6], antimicrobial [7], antibacterial [8], antioxidant [9], gastroprotective [10], neuroprotective [11], antifilarial [12], antimalarial [13], and analgesic activity [14]. The primary goal of this research was to evaluate the effect of P. betle L. leaves extract against clonidine-induced catalepsy and milk-induced leukocytosis and eosinophilia in mice
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