Abstract
In order to assess the effect of Carpolobia alba on male reproductive function, its aqueous extract was tested on lactate release by rat Sertoli cell cultures. The extract was administered daily to adult male rats. After 60 days of treatment, the animals were sacrificed and weight of organs (liver, kidneys, testes, epididymides, seminal vesicles and prostate) recorded. Liver glutathione levels and aniline hydroxylase activity, epididymal α-glycosidase activity, as well as serum testosterone level and aminotransferase activities were also assessed. Carpolobia alba extract at the doses 0.01 and 0.1 mg/kg significantly increased serum testosterone levels (P<0.01) in male rats, while other investigated parameters on serum and Sertoli cells remained unchanged. These results proved the androgenic effect of C. alba and thereby, sustain its use in the management of male infertility.
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