Abstract
In this paper, we report on the conformational analysis of several polyether triterpenes with a squalene carbon skeleton which exhibited significant cytotoxic activity using a Monte Carlo conformational search and spectroscopical data. These studies indicate that the conformation of the side chain C-14/C-19 and the arrangement and direction of this chain may be among the fundamental factors related to the activity of this type of metabolites. We report the conformational analysis of several polyether triterpenes with squalene carbon skeleton which exhibited a significant cytotoxic activity using a Monte Carlo conformational search and spectroscopical data.
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