Evaluation of the comparative efficacy of the control of arterial hypertension and improvement of the quality of life of patients with arterial hypertension after coronavirus infection using various regimens of three-component antihypertensive therapy

Abstract

In patients who have undergone coronavirus infection, decompensation of the course of chronic cardiovascular diseases, including arterial hypertension, is often observed, which is due to a number of their common pathogenetic mechanisms. To evaluate the comparative effectiveness of controlling arterial hypertension and improving the quality of life who underwent a new coronavirus infection. Totally 62 patients with arterial hypertension who had previously undergone coronavirus infection were examined. The criterion for inclusion in the study was a decrease in blood pressure control on the background of previously effective two-component therapy. Depending on the heart rate at rest, the patients were divided into two groups. In both groups, triple antihypertensive therapy was used as a second step. In the first group - a combination of perindopril 5 mg, indapamide 2.5 mg, amlodipine 5 mg. The second group included patients with a heart rate of more than 80 beats per minute, perindopril 5 mg, bisoprolol 5 mg, amlodipine 5 mg. The antihypertensive efficacy of the studied drug combinations was analyzed according to the data of 24-hour blood pressure monitoring. During the treatment of arterial hypertension, the dynamics of quality-of-life indicators was analyzed. A study of 24-hour monitoring and blood pressure variability in both groups of patients with coronavirus infection demonstrated the lack of effective blood pressure control. The use of the analyzed variants of three-component therapy made it possible to achieve the target level of blood pressure in 89.6% and 93.9% of cases, respectively. In both study groups, the achievement of office blood pressure control was accompanied by a statistically significant decrease in all its daily parameters. On the background of antihypertensive therapy in both groups of the study, there was a significant and reliable (p<0.05) increase in all parameters for assessing the quality of life, which reflects the effectiveness of the treatment of arterial hypertension in patients who have had a coronavirus infection in increasing satisfaction with their lives and improving social functioning. Therapy with the use of perindopril, bisoprolol, amlodipine was accompanied by the achievement of significantly (p<0.05) higher rates of mental and physical health components.