Abstract
Evaluation of the Binding Potential of Chrysophyllum albidum Seed Gum in Paracetamol Tablet Formulation
Highlights
Pharmaceutical excipients control the physicochemical properties as well as the release profiles and availability of the drug in the formulation
The materials employed in the study were Paracetamol B.P. (obtained as a gift from Vitabiotics Industry (Nig.) Ltd), Acacia gum (Pharma Grade Iso-9001;2008; CAS 9000-01-5; Titan Biotech Ltd, Bhiwadi301019,India),Chrysophyllum albidum seed gum (CasG) was obtained by extraction using the method that has been reported in a previous study,[11] Lactose, Corn starch BP, Magnesium stearate and Talc were gifts from Ecomed Pharma Ltd, Ota, Ogun State, Nigeria
There was no significant difference in the bulk and tap densities of the CasG-A, CasG-C and acacia gum (AcaG)-D but the values obtained for CasG-B was significantly (p < 0.05) lower
Summary
Pharmaceutical excipients control the physicochemical properties as well as the release profiles and availability of the drug in the formulation. One of such commonly used groups of compounds is natural polymers. They are polysaccharides composed of a large group of polymers with varying chemical compositions, and a wide range of molecular weights They are characterized by low toxicity, high stability and biodegradability. Binders are excipients added to tablet formulation to impart plasticity and increase the inter-particulate bonding strength within the tablet. They hold the ingredients in a tablet together and give volume to low active dose tablets.
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