Abstract
The electron dense arsenic inclusion was first reported to occur in the nucleus of hepatocytes of Lepomis cvanellus. a freshwater species of sunfish, following laboratory exposures of this species to solutions of arsenate. Markedly elevated levels of arsenic were reported in the livers of the green sunfish, apparently due to the enterohepatic redistribution of the metalloid following biliary excretion. A maximum of approximately 50 and 160 ppm arsenic was found in the liver and bile, respectively, following a 6-d exposure of these fish to 60 ppm arsenic at 20°C. Translocation of arsenic from a cytoplasmic to nuclear location occurred during a 6-d period, ultimately leading to an increase in the size and number of intranuclear inclusions in the parenchymal hepatocytes. Microprobe analysis data indicated that the inclusion was composed of arsenic in a one to six ratio with sulfur.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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