Abstract
The growing clinical importance of drug-resistant fungal and bacterial pathogens has given additional urgency to microbiological research and the development of new antimicrobial compounds. 1,2,4-Triazoles act as important pharmacophores by interacting with high affinity biological receptors due to their dipole character, hydrogen binding capacity, stiffness and solubility. Following the evaluation of the antifungal activity, Nitrotriazon has MIC/MFC values: from 0.07 to 0.19 mM compared to the reference drugs: Ketoconazole, Bifonazole. Nitrotriazone also showed good antibacterial activity with MIC / MBC values from 0.0006 to 0.0013 mM, compared to the reference drugs Ampicillin and Chloramphenicol. The antimycobacterial activity of Nitrotriazone against M. tuberculosis, the reference strain (H37Rw) and the extended resistance of M. tuberculosis (M/XDR) were also studied.
Highlights
0.19 mM compared to the reference drugs
Interaction of anti-tuberculosis preparations with drugs used in COVID-19 The COVID-19 pandemic has raised new global health issues
The treatment of these infections has raised from the outset the efficacy and safety assessment of combining antituberculosis drugs
Summary
EVALUAREA ACTIVITĂȚII ANTIFUNGICE ȘI ANTIBACTERIENE A UNUI NOU DERIVAT NESATURAT DE 1,2,4-TRIAZOL (NITROTRIAZON). În urma evaluării activității antifungice, Nitrotriazonul are valori ale CMI/CMF: de la 0,07 la 0,19 mM comparativ cu medicamentele de referință: Ketoconazol, Bifonazol. Evaluation of the antifungal and antibacterial action of a new unsaturated 1,2,4-triazole derivative (Nitrotriazon). Following the evaluation of the antifungal activity, Nitrotriazon has MIC/MFC values: from 0.07 to 0.19 mM compared to the reference drugs: Ketoconazole, Bifonazole. Nitrotriazone showed good antibacterial activity with MIC / MBC values from 0.0006 to 0.0013 mM, compared to the reference drugs Ampicillin and Chloramphenicol. The antimycobacterial activity of Nitrotriazone against M. tuberculosis, the reference strain (H37Rw) and the extended resistance of M. tuberculosis (M/XDR) were studied. Также была изучена антимикобактериальная активность нитротриазона против M. tuberculosis, эталонного штамма (H37Rw) и расширенную устойчивость M. tuberculosis (M/XDR). Ключевые слова: 1,2,4-триазол, антибактериальная активность, противогрибковая активность, антимикобактериальная активность
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