Evaluation of Serum Biochemical Parameters Primarily Liver Functions in Smokers: A Case-control Study

Abstract

We investigated the effects of smoking on serum biochemical parameters primarily liver functions and metabolism. This is a case-control study. The case and control groups were formed by clinical randomization by using the data obtained from the hospital information system and patient records, including age, gender, height, and weight. Smokers were identified as the case group, while non-smokers were identified as the control group. In the comparisons of rates Chi-square tests were used and in the comparisons of averages, independent sample t and MANCOVA tests were used. When covariance factors such as age, gender, body mass index, and alcohol use were taken into consideration, it found that AST, ALT, and GGT were higher in smokers, whereas vitamin D, vitamin B12, and TSH were higher in non-smokers. We found that smoking has a negative effect on liver and bile functions, and vitamin D values are affected secondary to this negative effect